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KMID : 1094720120170020407
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Biotechnology and Bioprocess Engineering
2012 Volume.17 No. 2 p.407 ~ p.412
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Lens culinaris: A new biocatalyst for reducing carbonyl and nitro groups
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Ferreira Daniele Alves
da Silva Roberio Costa
da Costa Assuncao Joao Carlos
de Mattos Marcos Carlos
de Lemos Telma Leda Gomes
Monte Francisco Jose Queiroz
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Abstract
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A series of aliphatic and aromatic aldehydes and ketones, as well as some nitrocompounds were reduced using whole plant cells from Lens culinaris seeds. In addition, we also investigated the possibility of enzymatic ester hydrolysis to explore the potential of these seeds. The reduced ketones products were obtained in yields of 8 ∼ 82% and enantiomeric excess of 39 ∼ 75%. Aldehydes were more reactive than ketones with high chemical yield (95→99%), whereas the aromatic nitrocompounds showed low (2%) to high (> 99%) conversion depending upon the nature and position of the aromatic ring substituents. Ester hydrolysis by the Lens culinaris was quite effective with the ester p-nitrophenyl acetate (> 99% conversion).
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KEYWORD
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Lens culinaris, bioreduction, ketone, aldehyde, nitrocompound
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